TABLE 2.
Associations Between Molecular Features, Poorly Cohesive Carcinoma Component, and Tumor Stage in Very Well-Differentiated Gastric Adenocarcinoma of Intestinal Type
| Tumor stage | PCC component | |||||
|---|---|---|---|---|---|---|
| Early | Advanced | Present | Absent | |||
| (n=45) | (n=13) | P | (n=31) | (n=27) | P | |
| PCC component | <0.001* | — | ||||
| Present | 18 | 13 | 31 | 0 | ||
| Absent | 27 | 0 | 0 | 27 | ||
| p53 immunohistochemistry | 0.0015 | 0.026 | ||||
| Mutation pattern | 1 | 5 | 6 | 0 | ||
| Wild-type pattern | 44 | 8 | 25 | 27 | ||
| RHOA | 0.88 | 0.92 | ||||
| G17E | 8 | 2 | 5 | 5 | ||
| Y42C | 7 | 1 | 5 | 3 | ||
| Other mutation | 2 | 0 | 1 | 1 | ||
| Wild type | 27 | 10 | 20 | 18 | ||
| ARID1A expression | 0.65 | 0.11 | ||||
| Retained | 40 | 11 | 25 | 26 | ||
| Loss | 5 | 2 | 6 | 1 | ||
| Mucin phenotype | <0.001 | <0.001 | ||||
| Mixed | 28 | 13 | 29 | 12 | ||
| Intestinal | 17 | 0 | 2 | 15 | ||
*
χ2 test (others: the Fisher exact test).
PCC indicate poorly cohesive carcinoma.