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. 2024 Apr 4;134(10):e177896. doi: 10.1172/JCI177896

Figure 2. Clinical trajectories of ARDS severity (Berlin mild, moderate, severe), MODS, and hyper-/hypoinflammatory ARDS subphenotype (defined using a parsimonious algorithm of IL-6, IL-8, CCL3/MIP-1α, and ANG2) over the first 7 days.

Figure 2

Top: Berlin ARDS trajectories are stratified according to whether patients have mild (gray), moderate (blue), or severe (green) on day 0; on day 3, patients are again restratified according to whether ARDS has resolved (olive), or is mild (aqua), moderate (red), or severe (blue) according to Berlin criteria. Middle: MODS trajectories are stratified according to whether patients have at least 2 nonpulmonary organ failures (aqua) or not (olive) on day 0; on day 3, patients are restratified according to whether they have at least 2 nonpulmonary organ failures (red) or not (blue). Bottom: Day 0 hypo- (olive) and hyperinflammatory (aqua) ARDS trajectories, and day 3 hypo- (blue) and hyperinflammatory (red) ARDS subphenotype are similarly labeled. By day 7, 45 patients had been discharged alive from the PICU, and 27 had died. Note that these 27 nonsurvivors within 7 days of ARDS onset represent a subset of the total (n = 64) who died in the PICU.