Figure 4. Differences in biomarkers of inflammation, tissue injury, and DAMPs between PICU survivors and nonsurvivors on days 0 (n = 279), 3 (n = 266), and 7 (n = 207) of ARDS.

Values represent estimated levels (and 95% CIs) after biomarkers underwent log transformation and multivariable adjustment (age, ARDS etiology, immunocompromised status, initial PaO₂/FIO₂). The y axis shows differences in biomarker levels presented as a fold change; the x axis shows the P value. The dotted lines indicate a fold change = 1 (i.e., no difference; horizontal line) and the Bonferroni-corrected P value threshold (unadjusted P = 0.0025, Bonferroni-corrected P = 0.05; vertical line). This P value of the t statistic tests the hypothesis that the coefficient from the regression model differs from 0. Red dots depict biomarkers at unadjusted P < 0.0025; black dots represent those with unadjusted P > 0.0025.