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. 2024 Mar 19;134(10):e169137. doi: 10.1172/JCI169137

Figure 2. Adherens junction protein expression in dermal microvasculature.

Figure 2

(A) VE-cadherin (VE-cad; green) or CD31 (red) immunostaining in representative skin biopsies; arrowheads indicate areas of decreased VE-cadherin expression (red), which is reflected in the black/white panels of individual immunostains (lower panels). (B) Ratio of VE-cadherin/CD31 immunostaining. Data indicate the mean ± SEM. n = 7 ISCLS; n = 4 controls. *P = 0.01 and **P = 0.001, by 2-way ANOVA with Šidák’s multiple comparisons. (C) p–VE-cadherinTyr685 (green, arrowheads) and CD31 (red) immunostaining in representative skin biopsies; black/white panels show the corresponding individual stains. (D) p–VE-cadherin/CD31 immunostaining (μm2) in histamine-challenged skin biopsies. Data indicate the mean ± SEM. n = 7 ISCLS; n = 4 controls. *P = 0.02, by Mann-Whitney U test. (E) Pearson’s correlation of p–VE-cadherin immunostaining with fibrinogen extravasation. Scale bars: 10 μm. Original magnification, ×63.