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. 2024 Mar 19;134(10):e169137. doi: 10.1172/JCI169137

Figure 3. Hyperresponsiveness of ISCLS-derived ECs in vitro.

Figure 3

Representative TER over time in BOEC monolayers stimulated with histamine (20 μM) (A), VEGF (100 ng/mL) (D), or thrombin (0.05 U/mL) (G). Data indicate the mean ± SD. Arrows indicated the time of agonist addition. (B, E, and H) Maximum decrease in TER elicited by the respective agonists. Data indicate the mean ± SEM. n = 7 ISCLS; n = 8 controls. *P = 0.01, by unpaired, 2-tailed Student’s t test. (C, F, and I) The AUC is shown for each agonist. Data indicate the mean ± SEM. n = 7 ISCLS; n = 8 controls. *P = 0.04, by unpaired, 2-tailed Student’s t test (C) and #P = 0.01, by Mann Whitney U test (F).