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. 2024 Apr 10;25(5):2220–2238. doi: 10.1038/s44319-024-00128-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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(A) Venn diagram shows an overlap between SE in LB-100-treated SW-480 and HT-29 cells (left). Gene Ontology (GO) analysis of SE events in SW-480 and HT-29, and an overlap is shown (right). BP biological process. (B) Alternative splicing event within ATM gene and representative Sashimi plots showing differential splicing in untreated and LB-100-treated SW-480 cells. (C) Representative protein analysis of ATM and Chk2 in LB-100-treated SW-480 cell line of human colorectal adenocarcinomas. Data information: In (A) p values were calculated with Fisher’s exact test. See also Fig. EV3. Source data are available online for this figure.