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. 2024 Apr 10;25(5):2220–2238. doi: 10.1038/s44319-024-00128-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Figure EV4 — (A–F) Motif RNA map shows SRSF1 (A), HNRNPA1 (B), HNRNPK (C), HNRNPL (D), HNRNPH2 (E), and HNRNPAB (F) proteins binding in the proximity of excluded (DOWN), included (UP), or not affected (NO) exons in LB-100-treated as compared to untreated SW-480 colorectal adenocarcinoma cells. (G) Location of mis-phosphorylated sites across SRSF1 protein. Functionally relevant protein regions according to UniProt are shown. Significantly changing phosphosites in response to LB-100 are highlighted. (H,I) Synergy matrices show a lack of cooperativity between LB-100 and isoginkgetin (H) or indisulam and pladienolide B (I) in the SW-480 human adenocarcinoma cell line. Representative heat map for n = 3 biological replicates. (J–M) Synergy matrices show a lack of cooperativity between LB-100 and indisulam (J), pladienolide B (K), isoginkgetin (L), or indisulam and pladienolide B (M) in HT-29 human adenocarcinoma cell line. Representative heat map for n = 3 biological replicates. Source data are available online for this figure.