Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Apr 8;25(5):2348–2374. doi: 10.1038/s44319-024-00130-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

PMC Copyright notice

(A) Specimen traces showing AMPAR-mediated spontaneous EPSCs (sEPSCs) and miniature EPSCs (mEPSCs) in the presence of 300 nM TTX of CA1 pyramidal cells. (B, C) Comparison of inter-event intervals of sEPSCs (B) and mEPSCs (C). (D) Specimen traces showing average mEPSCs kinetics of CA1 pyramidal cells. (E) Analysis of decay times of CA1 mEPSCs (AMPA receptor-evoked currents). (F) Comparison of peak amplitudes of sEPSCs and mEPSCs. Note that mEPSC amplitudes are not different amongst genotypes, suggesting no change in functional synaptic contacts, whereas action potential-dependent sEPSC amplitudes are larger in +/+ but not in Δ/Δ mice, indicating impairment in synaptic multiplicity in the latter. Data information: Data indicate mean ± SEM. Numbers on bars show tested cells and (the number of animals). P values are from unpaired Student’s t [C, E, F (for Δ/Δ and sEPSC comparison)] or Mann–Whitney tests [B, F (for +/+ and mEPSC comparison)]. Source data are available online for this figure.