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. 2024 Apr 8;25(5):2348–2374. doi: 10.1038/s44319-024-00130-9

Table 2.

Similar electrophysiological profile in the hippocampus of Csf1rΔFIRE/ΔFIRE mice compared to data from wild-type mice with microglial depletion at comparable ages.

Present study Basilico et al, 2022 Du et al, 2022 Parkhurst et al, 2013 Liu et al, 2021
Brain region Hippocampus CA1/3 Hippocampus CA1/3 Hippocampus CA1/3 Motor cortex L5 Visual cortex L5
Age 6–10 weeks 6–10 weeks 4–5 weeks 3–6 weeks 9–10 weeks
Microglial depletion Throughout life, 100% Transient (≈ 85–90%), postnatally/adolescence
Glutamatergic transmission graphic file with name 44319_2024_130_Taba_HTML.gif graphic file with name 44319_2024_130_Tabb_HTML.gif graphic file with name 44319_2024_130_Tabc_HTML.gif graphic file with name 44319_2024_130_Tabd_HTML.gif graphic file with name 44319_2024_130_Tabe_HTML.gif
• I/O (CA3–CA1) graphic file with name 44319_2024_130_Tabf_HTML.gif graphic file with name 44319_2024_130_Tabg_HTML.gif graphic file with name 44319_2024_130_Tabh_HTML.gif n.d. n.d.
• release probability – graphic file with name 44319_2024_130_Tabi_HTML.gif – n.d. n.d.
• mEPSC (AMPAR) Freq – amp – Freq – amp – n.d. Freq Inline graphic amp – n.d.
• multivesicular release graphic file with name 44319_2024_130_Tabk_HTML.gif graphic file with name 44319_2024_130_Tabl_HTML.gif n.d. n.d. n.d.
• NMDAR (postsyn.) graphic file with name 44319_2024_130_Tabm_HTML.gif graphic file with name 44319_2024_130_Tabn_HTML.gif n.d. graphic file with name 44319_2024_130_Tabo_HTML.gif n.d.
GABAergic transmission — — n.d. n.d. graphic file with name 44319_2024_130_Tabp_HTML.gif
• m/sIPSCs – – n.d. n.d. n.d.

Key to symbols and abbreviations:

Inline graphic / Inline graphic / –, increase/decrease/no change, n.d. not determined.

mEPSC miniature excitatory postsynaptic current, m/sIPSC miniature/spontaneous inhibitory postsynaptic curren, freq frequency, amp amplitude, I/O Input/Output relationship referring to CA1 compound EPSCs in response to CA3 electrical stimulation, AMPA alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid, NMDAR N-methyl-d-aspartate receptor, GABA gamma-aminobutyric acid.