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. 2024 Mar 18;25(5):2278–2305. doi: 10.1038/s44319-024-00117-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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(A) SorLA is present in Iba1+ cells in some patients (#1) but absent from these cells in other cases (#2). White arrowheads indicate selected Iba1+ cells. Scale bars, 25 µm. (B) UMAP plot showing SORL1 expression levels normalized with SCT, in clusters of human GAMs. (C) Selected marker genes of 5 GAMs clusters with the highest and 5 clusters with the lowest SORL1 expression levels. CL#, cluster number; FC, SORL1 expression fold change, mean cluster expression against mean expression in remaining clusters. (D) Hierarchical clustering of the most significant genes based on the mean values of standardized gene expression data. These genes were returned by MCFS-ID with the highest RI values and showed differential expression in the context of discretized values of SORL1 gene expression.