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. 2024 May 14;14:10983. doi: 10.1038/s41598-024-61844-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Shortest path length distribution of genes to PINK1gene in the PPI network. We represent the background gene set as group (1) (blue) and Core PD predictions set as group (2) (red), indicating the number of genes in each set in the brackets on the right. MWU (2) < (1) indicates that we perform a one-sided MWU (with a significance level of 0.05) to test if the shortest path distribution of Core PD predictions is significantly smaller than the one of background genes (with p-value $< 0.05$ indicated by *). (b) PPI network of PINK1and its 36 first neighbours from Core PD predictions. Network visualization was done using Cytoscape 3.10.0⁵⁰.