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. 2024 May 1;15:1398135. doi: 10.3389/fphar.2024.1398135

FIGURE 2.

FIGURE 2

Fa-CI plot of combined treatments of ExtTa with DOX in Saos-2 osteosarcoma cells and with 5-FU in HCT116 colorectal cancer cells. The combination index was calculated using CompuSyn software. Dose-effect curve for ExtTa + DOX (A) and ExtTa + 5-FU (E); Median-effect plot for ExtTa + DOX (B) and ExtTa + 5-FU (F). Combination index (CI) for ExtTa + DOX (C) and ExtTa + 5-FU (G); Dose-reduction index (DRI) for the combination of the ExtTa + DOX (D) and ExtTa + 5-FU (H). Fa, fraction affected; ExtTa, Ethanolic Extract T. asperelloides; DOX, doxorubicin; ExtDOX, combined treatments of Ethanolic Extract T. asperelloides and doxorubicin; 5-FU, 5-fluorouracil; Ext5FU, combined treatments of Ethanolic Extract T. asperelloides and 5-fluorouracil.