TABLE 1.

ExtTa and DOX Selectivity Index (SI) values for tumor cell lines using GM637, HEK-293T, NIH/3T3, and L929 non-cancer cells as reference.

Selectivity Index (SI*)
Reference non tumor cells	GM637		HEK-293T		NIH/3T3		L929
Cancer cell lines	Treatment
	ExtTa	DOX	ExtTa	DOX	ExtTa	DOX	ExtTa	DOX
T98G	3.97	NS	3.03	NS	2.68	NS	3.13	NS
MDA-MB-231	1.80	NS	1.37	NS	1.21	NS	1.42	NS
A549	1.13	NS	0.86	NS	0.76	NS	0.89	NS
HCT116	3.93	NS	2.99	NS	2.65	NS	3.10	NS
LB373	1.87	NS	1.43	NS	1.26	NS	1.48	NS
HT1080	2.77	1.00	2.11	9.25	1.87	NS	2.18	NS
WiDr	2.71	NS	2.07	1.95	1.83	NS	2.14	NS
Saos-2	2.76	NS	2.10	2.05	1.86	NS	2.17	NS

*SI, ratio between the IC50 of non-cancer cells and cancer cells. The values in bold represent the highest selectivity indices (SI)

NS = SI < 1.0.