Figure 3.

Associations between dietary/nutritional factors and future VoD in those with and without a neurogenesis-centred biological susceptibility 12 years prior to condition onset. (A) Table presenting the multivariable-adjusted associations between dietary/nutritional factors and future VoD by neurogenesis-centred biological susceptibility status (i.e., %SOX2 levels—hippocampal progenitor cell integrity). (a) Represents the median for %SOX2 levels. (b) OR are for 1-SD increase in dietary factor. Analysis: Logistic Regression. Model 1: adjusted for age, sex, level of education, and age of dementia onset. Model 2: fully adjusted. Adjusted as per Model 1 plus physical exercise, plasma cholesterol levels, plasma glucose levels, diabetes, hypercholesterolemia, antihypertensive medication use, diabetic medication use, and psychotropic medication use. (B) Regression coefficient plot representing the associations between key dietary/nutritional factors and future VoD in those with and without a neurogenesis-centred biological susceptibility. Increased vitamin D consumption increased the risk for future VoD, but only in individuals with a neurogenesis-centred biological susceptibility (i.e., reduced (≤median) baseline levels of hippocampal progenitor cell integrity). Abbreviations: SOX2, SRY (sex determining region Y)-box 2; OR, odds ratio, CI, confidence intervals, ApoE-ε4, allele ε4 for the apolipoprotein E gene. FDR corrected P values; ^*P < 0.05.