Figure 4.

Associations between dietary/nutritional factors and depressive symptomatology across a 12-year period in those with and without a neurogenesis-centred biological susceptibility. (A) Table presenting the multivariable-adjusted associations between dietary/nutritional factors and any depressive symptomatology across a 12-year period by neurogenesis-centred biological susceptibility status (i.e., %MAP2 levels—hippocampal cell differentiation). (a) Represents the median for %MAP2 levels. (b) OR are for 1-SD increase in dietary factor. Analysis: logistic regression. Model 1: adjusted for age, sex, level of education, and baseline depressive symptomatology. Model 2: fully adjusted. Adjusted as per Model 1 plus physical exercise, and plasma glucose levels. (B) Regression coefficient plot representing the associations between key dietary factors and any depressive symptomatology in those with and without a neurogenesis-centred biological susceptibility. Increased plasma γ-tocopherol concentrations (a vitamin E biomarker) increased the risk of having any depressive symptomatology, but only in individuals with a neurogenesis-centred biological susceptibility (i.e., higher (≥median) baseline levels of hippocampal cell differentiation). Abbreviations: MAP2, microtubule-associated protein 2; OR, odds ratio; CI, confidence intervals. FDR corrected P values; ^*P < 0.05.