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. Author manuscript; available in PMC: 2024 May 15.
Published in final edited form as: Neuropharmacology. 2024 Feb 15;248:109866. doi: 10.1016/j.neuropharm.2024.109866

Figure 3. LY2817412 modulates GABA release onto VTA DA neurons.

Figure 3.

(A) Representative sIPSCs traces recorded from putative VTA DA neurons before (Baseline), during LY2817412 (1 μM), and during picrotoxin (100 μM) slice perfusion. Scale bars: 50 pA × 2 s. (B-C) Bar graphs showing the effects of LY2817412 (1 μM) on frequency (D) and amplitude (E) of sIPSCs. (D). Representative mIPSCs traces recorded from putative VTA DA neurons before (vehicle), during TTX (1 μM), TTX + LY2817412 (1 μM), and during TTX + LY2817412 + picrotoxin (100 μM) slice perfusion. Scale bars: 50 pA × 2 s. (E-F) Bar graphs showing the effects of LY2817412 (1 μM) on frequency (D) and amplitude (E) of mIPSCs.