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. Author manuscript; available in PMC: 2024 May 15.
Published in final edited form as: Neuropharmacology. 2024 Feb 15;248:109866. doi: 10.1016/j.neuropharm.2024.109866

Figure 4. Effects of N/OFQ on VTA DA neuronal firing discharge is not altered by blockade of GABARs.

Figure 4.

(A) Representative and averaged temporal changes of firing rate of putative VTA DA recorded neurons before, during, and after N/OFQ (0.3 μM) slice perfusion in absence, or in presence of picrotoxin (100 μM) and CGP55845 (1 μM). Scale bar: 1 s. (B) Bar graphs represent the averaged peak effects of N/OFQ in the firing rate of VTA DA neurons in absence, and in presence of picrotoxin and CGP55845 pretreatment. ** p < 0.01.