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. Author manuscript; available in PMC: 2024 May 15.
Published in final edited form as: Neuropharmacology. 2024 Feb 15;248:109866. doi: 10.1016/j.neuropharm.2024.109866

Figure 5. LY2817412 decreases VTA DA firing activity in a GABAB receptors-mediated manner.

Figure 5.

(A-E) The graphs show representative and averaged traces of the spontaneous firing from putative VTA DA neuron before, during, and after LY2817412 (1 μM) slice treatment in (A) absence, and in presence of (B) picrotoxin (100 μM) + CGP55845 (1 μM), (C) picrotoxin (100 μM), (D) CGP55845 (1 μM), or (E) naloxone (10 μM). Scale bar: 1 s. (F) Bar graphs represent the averaged maximal effects of LY2817412 on the firing rate of VTA DA neurons in the same experimental conditions. *** p < 0.001, ### p < 0.001.