TABLE F.1 Parameters considered in the EOGRT study with the corresponding generation/cohort/number of animals for each.
| Generation | P | F1 pups (surplus) | F1 C1A | F1 C1B | F2 |
|---|---|---|---|---|---|
| Number of animals examined/sex per group | 25 | All | 20 | 20 | All |
| Mortality | X | X | X | X | X |
| Clinical signs | X | X | X | X | |
| Behavioural examination during lactation | X | X | X | X | |
| Detailed clinical examination | X | X | X | X | X |
| Body weight | X | X | X | X | X |
| Feed consumption | X | X | X | ||
| Haematology | X | X | |||
| Clinical biochemistry | X | X | |||
| Lymphocyte typing (spleen) | X | ||||
| Urinalysis | X | X | |||
| Thyroid hormone levels | X | X | X | ||
| Sexual maturation | X | X | X | ||
| Oestrous cycle data | X | X | X | ||
| Sperm parameters | X | X | |||
| Necropsy and gross pathology | X | X | X | X | X |
| Organ weight | X | X | X | X | |
| Histopathology | X | X | |||
| Reproductive parameters | X | X | |||
| Pre‐postnatal development | X | X | X | X | X |
| Sensory reflexes | X | X | X | X |
Note: A qualitative overview of the parameters analysed in the EOGRT study on naringenin is summarised in the tables below for each generation (P, F1 and F2). For the measured parameters, it is reported if a statistically significant change was observed (increase (↑) or decrease (↓)) or not (−). For a detailed explanation, see Section 3.4.4.2.