TABLE F.4 Parameters examined in F2 generation animals. Only statistically significant changes are reported; ‘‐’: no statistically significant changes were observed. Dose groups: G1: 0, G2: 16,000, G3: 20,000, G4: 25,000 mg/kg feed. Unless specified differently, the reported values for the respective parameters are within the historical control ranges.
| Parameters examined | F2 males | F2 females |
|---|---|---|
| Sex ratio and litter size | – | – |
| Mortality | – | – |
| Clinical signs | – | – |
| Behavioural examination during lactation | – | – |
| Detailed clinical examination | – | – |
| Body weight | PND1: ↓ G4 | PND4: ↓ G4 |
| PND14: ↓ G3 and G4 | ||
| Sexual maturation (AGD and AGD ratio) | ↑ G4 | – |
| Necropsy and gross pathology | – | – |
| Pre‐postnatal development (postnatal fur development) | ↑ G3 | ↑ G3 |
| Sensory reflexes | – | – |
Abbreviations: ‘–’, statistically not significant; ↑, increase; ↓, decrease; G, dose group; PND, post‐natal day.