Table 2.

Results of primary and secondary outcomes at three years

Outcome	Long acting progestogen*	Combined oral contraceptive pill*	Adjusted mean difference (95% CI)
Primary outcome—EHP-30 pain score†
Baseline	56.6 (17.3), 197	55.8 (19.9), 192	—
3 years	32.9 (25.0), 173	32.9 (27.6), 164	−0.8 (−5.7 to 4.2)‡
Secondary outcome—EHP-30 core domains†
Control and powerlessness
Baseline	69.1 (19.7), 198	66.6 (23.4), 193	—
3 years	40.9 (28.5), 103	45.4 (34.2), 99	−2.4 (−10.0 to 5.2)
Social support
Baseline	56.8 (23.5), 198	56.5 (26.5), 193	—
3 years	40.7 (31.5), 102	48.4 (36.1), 99	−5.1 (−12.6 to 2.5)
Emotional wellbeing
Baseline	53.0 (20.3), 198	52.4 (23.2), 193	—
3 years	35.6 (26.6), 103	38.6 (31.1), 99	−1.8 (−8.2 to 4.7)
Core domain: self-image
Baseline	54.3 (28.4), 198	52.6 (29.0), 194	—
3 years	43.7 (34.4), 103	48.1 (36.7), 99	−1.7 (−9.6 to 6.2)
Secondary outcome—EHP-30 modular domains†
Work life
Baseline	51.2 (25.9), 165	50.2 (28.0), 168	—
3 years	23.5 (25.4), 94	23.2 (27.4), 79	−0.7 (−8.5 to 7.1)
Relationship with children
Baseline	40.5 (29.9), 107	33.5 (26.6), 87	—
3 years	19.9 (25.8), 47	19.3 (28.7), 42	−4.2 (−14.7 to 6.4)
Sexual relationship
Baseline	68.4 (26.0), 173	69.6 (24.3), 169	—
3 years	53.4 (31.7), 87	55.9 (32.5), 87	−0.0 (−8.4 to 8.4)
Feelings about medical profession
Baseline	36.0 (29.0), 169	31.2 (27.9), 162	—
3 years	41.3 (33.0), 53	43.1 (34.1), 58	−3.4 (−15.0 to 8.1)
Feelings about treatment
Baseline	48.3 (26.1), 121	46.4 (27.5), 115	—
3 years	40.4 (27.2), 65	39.1 (32.7), 67	2.5 (−8.7 to 13.7)
Feelings about infertility
Baseline	49.9 (32.5), 110	48.5 (33.7), 110	—
3 years	55.9 (31.2), 35	44.9 (36.3), 45	4.3 (−9.8 to 18.4)
Secondary outcome—pelvic pain using visual analogue scale§
Pain during periods
Baseline	7.8 (1.4), 158	7.9 (1.5), 152	—
3 years	7.0 (1.7), 44	7.0 (2.1), 53	−0.4 (−1.2 to 0.4)
Pain during intercourse
Baseline	6.4 (2.4), 150	6.4 (2.6), 159	—
3 years	5.4 (3.0), 63	5.6 (2.8), 74	0.2 (−0.6 to 1.1)
Pain at any other time
Baseline	6.4 (2.0), 180	5.8 (2.1), 175	—
3 years	5.3 (2.3), 81	5.4 (2.5), 78	0.3 (−0.4 to 1.0)
Secondary outcome—Fatigue Severity Score¶
Baseline	43.6 (14.1), 197	42.3 (13.4), 191	—
3 years	43.0 (15.1), 102	42.0 (17.1), 98	1.5 (−2.0 to 5.1)
Secondary outcome—EQ-5D-5L**
Baseline	0.63 (0.24), 198	0.63 (0.24), 190	—
3 years	0.69 (0.27), 176	0.69 (0.29), 167	−0.01 (−0.06 to 0.04)
Secondary outcome—Likert scale changes in pelvic pain,†† number (%)
Got much better	5 (6)	5 (6)	0.83 (0.44 to 1.57)‡‡
Got a little better	4 (5)	6 (8)
Not changed much	42 (50)	38 (48)
Got worse	33 (39)	30 (38)
Total number	84	79
Secondary outcome—still experiencing periods (menstrual status), number (%)
Yes	51 (51)	62 (63)
No	50 (50)	36 (37)
Total number	101	98
Secondary outcome—menstrual cycle regularity, number (%)
Regular	12 (25)	13 (21)	1.43 (0.63 to 3.24)‡‡,§§
Fairly regular	15 (31)	16 (26)
Irregular	15 (31)	24 (39)
Bleeding on and off	6 (13)	8 (13)
Total number	48	61

CI=confidence interval; EHP-30=Endometriosis Health Profile 30; LAP=long acting progestogen; SD=standard deviation.

^*Data are mean (standard deviation), number.

^†EHP-30 pain domain; score ranges from 0 (not affected) to 100 (worst affected).

^‡Differences <0 favour LAP.

^§Visual analogue scale scores range from 0 (best outcome) to 10 (worse outcome); scores <0 favour LAP.

^¶Fatigue Severity Scale scores range from 9 to 63 (higher score=greater fatigue severity); scores <0 favour LAP.

^**EQ-5D-5L scores range from −0.59 (worse outcome) to 1.00 (best outcome); scores >0 favour LAP.

^††Odds ratio from proportional odds model shown; estimates <1 favour LAP.

^‡‡Adjusted odds ratio (95% confidence interval).

^§§Centre removed from model owing to lack of convergence.