Table 2.

Initial treatment strategies for patients with CAP. Adapted from Candel et al. [17].

Primary care regimen	Hospital admission regimen	ICU admission regimen
Oral amoxicillin 1g/8h or oral amoxicillin-clavulanic 875/125 mg/8h (if asthma or COPD) or cefditoren 400mg/12h (alternative)	Ceftriaxone 2g/24h iv or cefotaxime 2g/8h iv or ceftaroline 600mg/12h iv (if post-influenza pneumonia or risk of S. aureus)	Ceftriaxone 2g/24h iv or cefotaxime 2g/8h iv or ceftaroline 600mg/12h iv
	Plus	Plus
Macrolide (oral azithromycin 500mg/24h/ 3 days or clarithromycin 500mg/12h)	Oral/iv macrolide (azithromycin 500mg/24h /3 days or clarithromycin 500mg/12h)	Macrolide (azithromycin 500mg/24h iv or clarithromycin 500mg/12h iv) or quinolone (levofloxacin 500mg/12h or moxifloxacin 400mg/24h)
or	or
Levofloxacin500mg/12h (1-2 days) and then 500mg/24h or Moxifloxacin 400mg/24h	Levofloxacin 500mg/12h iv (1-2 days) and then 500mg/24h or moxifloxacin 400mg/24h iv	If risk factors for MDR bacteria: Meropenem 1g/8h iv + Levofloxacin 500 mg/12h iv + Ceftaroline 600mg/12h iv or Linezolid 600mg/12 h iv