FIGURE 2.

Connections between our integrated study findings and proposed mechanisms of TD‐ and BB‐induced direct vasodilatation and long‐term BP reduction. Our identified canonical pathways commonly shared between our metabolic signals associated with PRA and %GWAA are involved in the regulation of Rho kinase cascade, production of the vasodilators NO and prostacyclin, and production of the vasoconstrictors thromboxane A2, and endothelin‐1; the pathways proposed to underlie TD‐ and BB‐induced vasodilatation and long‐term BP reduction. GWAA, genetic West African ancestry; TD, thiazide diuretics; BB, β‐blockers; BP, blood pressure; PRA, plasma renin activity; S1P, sphingosine 1‐phosphate; eNOS, endothelial nitric oxide synthase.