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. 2024 May 15;22:460. doi: 10.1186/s12967-024-05284-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — CCT6A was highly expressed in LUAD and negatively correlated with the prognosis. (A) Heatmap of the CCT family gene expression in LUAD based on TCGA. (B) Univariate Cox analysis of the prognosis-related CCT family genes based on TCGA. (C) Multivariate Cox analysis of the prognosis-related CCT family genes based on TCGA. (D) Unpaired (left) and paired (middle) t tests of CCT6A expression between LUAD and normal tissues and ROC curve showing the sensitivity and specificity to predict the occurrence of LUAD (right) based on TCGA. (E) Kaplan Meier plots showing the significant difference of OS (left) and PFS (right) in LUAD patients between the CCT6A-high and CCT6A-low samples based on GSE68465. (F) Representative IHC plots of tumor and paired normal tissues (20×magnification). Scale bars = 200 μm. (G) Paired t tests of the H-score between tumor and normal tissues. (H) Kaplan Meier plots showing the significant difference of OS in LUAD patients with CCT6A-high and CCT6A-low tissues. (I) CCT6A protein expression in normal lung epithelial cell line and different LUAD cell lines. (J) CCT6A mRNA expression in normal lung epithelial cell line and different LUAD cell lines. (K) The transfection efficiency of shRNAs and plasmid in A549 and PC9 cell lines