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. 2024 May 15;4(3):oeae038. doi: 10.1093/ehjopen/oeae038

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© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Study protocol. Within the derivation cohort, 835 subjects (Sheffield centre) were referred over an 8-year period (2012–20) for further assessment of breathlessness. Cardiovascular magnetic resonance and right heart catheterization were performed within 24 h of each other. A sex-specific cardiovascular magnetic resonance–derived pulmonary capillary wedge pressure equation was derived, which included left ventricular mass and left atrial volume as cardiovascular magnetic resonance metrics. Within the validation cohort, 434 subjects (Leeds centre) with a diagnosis of heart failure in the preceding 12 months underwent cardiovascular magnetic resonance. The sex-specific cardiovascular magnetic resonance–derived pulmonary capillary wedge pressure equations were applied. CMR, cardiac magnetic resonance; PCWP, pulmonary capillary wedge pressure; RHC, right heart catheterization.