TABLE 4.
Level of viral replication in warts induced by CRPVb and CRPVa in domestic rabbits
| Virus inducing warts | Proportion (%) of specimens positivea for:
|
Mean no. of cells/mm2 ± SEM positiveb for:
|
||
|---|---|---|---|---|
| Viral DNA | Capsid antigens | Viral DNA | Capsid antigens | |
| CRPVb | 30/31 (96.8) | 22/31 (71) | 7.92 ± 1.92 | 2.22 ± 0.76 |
| CRPVa | 12/17 (70.6) (P = 0.017) | 4/17 (23.5) (P = 0.0005) | 0.73 ± 0.25 (P < 0.0001) | 0.12 ± 0.078 (P = 0.0012) |
a
Specimens were considered positive with at least one positive cell observed in the wart section analyzed by in situ hybridization or immunochemistry. Proportions of CRPVb- and CRPVa-positive specimens were compared using Fisher's exact test.
b
Positive cells were numerated in each section as described in Materials and Methods. The numbers of positive cells per square millimeter found for each specimen were used to calculate the mean numbers of positive cells per square millimeter for CRPVa- and CRPVb-positive specimens. The two-tailed P values were calculated using the nonparametric Mann-Whitney test.