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. 2024 Mar 15;11(18):2307233. doi: 10.1002/advs.202307233

Figure 3.

Figure 3

GABA recapitulated the prophylactic effect of L. reuteri against I/R. A) Levels of GABA detected in the serum and heart tissues by ELISA after 7 days of continuous GABA gavage. Data are shown as the mean ± SEMs. n = 4 per group. **, p < 0.01; ***, p < 0.001 (Student's t‐test). B) Scheme of the experiment with GABA gavage. Male C57BL/6J mice were treated with GABA gavage for 7 days before I/R and then continued for another 7 days after I/R. Cardiac function was detected by transthoracic echocardiography at baseline and 7 days after I/R. C) The ratios of heart weight to body weight (HW/BW) and heart weight to tibial length (HW/TL) at 7 days after I/R. Data are shown as the mean ± SEMs. n = 5 per group. ***, p < 0.001 (one‐way ANOVA with post hoc Tukey test). D) Representative echocardiographic images at baseline and 7 days after I/R. Quantitative data on LVEF, LVFS, LVEDD, and LVESD at 7 days after I/R are shown as the mean ± SEMs. Sham group (Sham), n = 7; PBS‐gavaged I/R group (PBS+I/R), n = 7; GABA‐gavaged I/R group (GABA+I/R), n = 5. **, p < 0.01; ***, p < 0.001 (one‐way ANOVA with Dunnett's test).