TABLE 1.
Demographics, clinical characteristics, and neuroimaging measures in study participants.
| Variables | Aβ positive (n = 27) | Aβ negative (n = 42) | P‐value |
|---|---|---|---|
| Demographics | |||
| Age, years, mean (SD) | 79.69 (6.84) | 74.22 (8.67) | 0.02 * , a |
| Sex, female, n (%) | 13 (48.1%) | 19 (43.2%) | 0.68 b |
| Education, years | 15.85 (3.79) | 14.48 (3.37) | 0.12 a |
| Vascular risk factors | |||
| Hypertension, n (%) | 21 (77.8%) | 32 (72.7%) | 0.64 b |
| Diabetes mellitus, n (%) | 4 (14.8%) | 3 (6.8%) | 0.27 b |
| Hyperlipidemia, n (%) | 21 (77.8%) | 26 (59.1%) | 0.11 b |
| Smoking, n (%) | 13 (48.1%) | 17 (40.4%) | 0.53 b |
| Cardiovascular disease, n (%) | 11 (40.7%) | 16 (38.1%) | 0.83 b |
| Previous TIA, n (%) | 8 (29.6%) | 11 (25.0%) | 0.67 b |
| Previous stroke, n (%) | 3 (11.1%) | 13 (29.5%) | 0.07 b |
| Neuroimaging | |||
| ST‐TIV, cm3 | 1239 (111.44) | 1196.90 (320.90) | 0.51 c |
| BPF, % | 69.98 (3.59) | 72.03 (5.41) | 0.07 a |
| WMH volume, cm3 | 36.87 (23.81) | 38.07 (21.14) | 0.82 c |
| Frontal | 13.38 (9.97) | 14.75 (9.42) | 0.49 c |
| Parietal | 16.21 (12.61) | 16.02 (9.93) | 0.80 c |
| Temporal | 4.36 (3.49) | 4.29 (3.06) | 0.67 c |
| Occipital | 2.79 (2.16) | 2.61 (2.06) | 0.69 c |
| Basal ganglia/thalamic | 0.52 (0.75) | 0.65 (1.03) | 0.89 c |
| Lacunes, mm3 | 860.81 (593.44) | 890.18 (1125.12) | 0.93 c |
| PVS, mm3 | 112.93 (104.44) | 148.93 (120.39) | 0.49 c |
| Hippocampal volume, cm3 | 5.12 (0.94) | 5.83 (0.96) | 0.003 * , a |
| Left | 2.54 (0.43) | 2.85 (0.47) | 0.02 * , a |
| Right | 2.58 (0.55) | 2.99 (0.53) | 0.01 * , a |
| Cognition | |||
| MMSE, /30 | 26.13 (2.92) | 27.25 (2.42) | 0.02 * , a |
| MoCA, /30 | 20.07 (4.17) | 22.73 (5.35) | 0.02 * , a |
Note: Raw neuroimaging volumetrics are reported in the table, but statistical analyses were conducted with ST‐TIV corrected values. P‐values comparing Aβ‐positive versus Aβ‐negative subjects. Values represent mean (standard deviation) or count (percentage).
Abbreviations: Aβ, amyloid beta; BPF, brain parenchymal fraction; MMSE, Mini‐Mental State Examination; MoCA, Montreal Cognitive Assessment; PVS, perivascular spaces; SD, standard deviation; ST‐TIV, supratentorial total intracranial volume; TIA, transient ischemic attack; WMH, white matter hyperintensities.
a
Student t test.
b
Chi‐squared test.
c
Wilcoxon rank‐sum test.
*
P‐value < 0.05.