TABLE 2.

Association between Aβ status and WMH volume with hippocampal volume.

Predictor	β coefficient between predictor and HV a	P‐value a	Interaction term Aβ status × WMH volume b	P‐value b
Age, years	−0.46	<0.0001 *	–	–
Sex, female, n	0.39	<0.0001 *	–	–
Education, years	−0.19	0.03 *	–	–
Aβ positive, n	−0.20	0.03 *	–	–
Frontal WMH, cm3	−0.26	0.03 *	−0.11	0.61
Parietal WMH, cm3	0.30	0.07	−0.02	0.82
Temporal WMH, cm3	0.25	0.18	0.23	0.16
Occipital WMH, cm3	−0.35	0.01 *	0.05	0.77
Basal ganglia/ thalamic WMH, cm3	0.23	0.31	0.07	0.81

Abbreviations: Aβ, amyloid beta; HV, hippocampal volume; WMH, white matter hyperintensities.

^a Multivariable linear regression model with hippocampal volume as the outcome and age, sex, education, Aβ status, regional WMH as predictors.

^b Interaction terms added to the linear regression model separately.

^* P‐value < 0.05, bias‐corrected bootstrapping with 5000 replications and 99% confidence interval.