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. 2024 Mar 16;20(5):3179–3192. doi: 10.1002/alz.13764

FIGURE 2.

FIGURE 2

Diagnostic performance of APS2. APS2 was statistically significantly higher (p < 0.001) in CL > 25 participants (A). Blue line shows optimal cut point (by Youden) of 47.5. AUC‐ROC for individual analytes as well as APS2 result (B). The AUC‐ROC for p‐tau217 concentration (0.91, 95% CI: 0.89 to 0.94) was significantly lower than the AUC‐ROC for %p‐tau217 (0.94, 95% CI: 0.92 to 0.96, p < 0.0001, DeLong comparison). The AUC‐ROC for APS2 (0.94, 95% CI: 0.92 to 0.96) was not significantly different from the AUC‐ROC for %p‐tau217 (p = 0.27, DeLong comparison). APS2, Amyloid Probability Score 2; AUC‐ROC, area under receiver operating characteristic curve; CI, confidence interval; CL, Centiloid.