TABLE 1.
Demographic characteristics of participants divided by country.
| Variable | Spain | France | Germany | The Netherlands | UK | p‐Value of comparison |
|---|---|---|---|---|---|---|
| n | 311 | 188 | 42 | 417 | 377 | |
| Sex | ||||||
| Male | 169 (54.3) | 89 (47.3) | 25 (59.5) | 262 (62.8) | 197 (52.3) | 0.003 |
| Female | 142 (45.7) | 99 (52.7) | 17 (40.5) | 155 (37.2) | 180 (47.7) | |
| Mean age at assessment (SD) | 45.19 (10.83) | 49.86 (7.43) | 37.48 (13.6) | 51.69 (5.05) | 40.91 (13.51) | <0.001 |
| Level of ID | ||||||
| Mild | 63 (20.3) | 20 (10.9) | 21 (50.0) | 54 (12.9) | 137 (37.0) | <0.001 |
| Moderate | 160 (51.4) | 124 (67.4) | 15 (35.7) | 203 (48.7) | 175 (47.3) | |
| Severe | 88 (28.3) | 40 (21.7) | 6 (14.3) | 160 (38.4) | 58 (15.7) | |
| AD diagnosis | 87 (28.0) | 48 (25.5) | 12 (28.6) | 65 (15.6) | 64 (17.1) | <0.001 |
| Mean age of AD diagnosis (SD) | 53.47 (5.53) | 55.6 (6.8) | 53.62(5.24) | 55.13 (4.15) | 51.4 (7.02) | 0.002 |
| AD decline rating | ||||||
| No cognitive decline | 181 (58.2) | 104 (55.3) | 22 (52.4) | 219 (58.9) | <0.001 | |
| Cognitive concern other causes | 18 (5.8) | 28 (14.9) | 4 (9.5) | 45 (12.1) | ||
| Possible/ prodromal AD | 25 (8.0) | 8 (4.3) | 4 (9.5) | 44 (11.8) | ||
| Definite AD | 87 (28.0) | 48 (25.5) | 12 (28.6) | 64 (17.2) | ||
| Current mental health diagnosis | ||||||
| Yes | 28 (9.0) | 67 (35.6) | 12 (29.3) | 83 (22.8) | <0.001 | |
| Currently prescribed psychotropic medication | ||||||
| Yes | 126 (50.0) | 66 (35.1) | 7 (17.5) | 75 (20.1) | <0.001 | |
| Epilepsy/seizures diagnosis | ||||||
| Yes | 61 (19.6) | 35 (18.6) | 7 (17.1) | 87 (24.4) | 57 (16.9) | 0.15 |
| Sleep problems | ||||||
| Yes | 30 (10.1) | 88 (46.8) | 4 (9.8) | 43 (12.4) | 38 (11.4) | <0.001 |
| Hypothyroidism | ||||||
| Yes | 145 (46.8) | 103 (54.8) | 22 (53.7) | 88 (23.5) | 147 (40.8) | <0.001 |
| Current or history of sensory problems (hearing and/or vision) | ||||||
| Yes | 148 (61.9) | 69 (36.7) | 7 (17.5) | 337 (82.4) | 318 (84.6) | <0.001 |
| Any other medical comorbidity | ||||||
| Yes | 82 (43.6) | 32 (80.0) | 287 (76.5) | <0.001 | ||
| APOE status | ||||||
| Non‐e4 | 238 (79.6) | 142 (77.2) | 305 (73.1) | 268 (71.1) | 0.04 | |
| e4 carriers | 57 (19.1) | 39 (21.2) | 94 (22.5) | 101 (26.8) | ||
| e2: e4 | 4 (1.3) | 3 (1.6) | 18 (4.3) | 8 (2.1) |
Notes: Percentage in parentheses unless otherwise stated.
Abbreviations: APOE, apolipoprotein E; ID, intellectual disability; UK, United Kingdom;