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. 2024 Mar 19;20(5):3251–3269. doi: 10.1002/alz.13789

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© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Associations of ALPS indexes with risk of clinical progression. The Kaplan–Meier curves of clinical progression to MCI/AD dementia in non‐demented participants (A), progression to MCI/AD dementia in CN participants (B), or progression to AD in UKB participants (C). Results of multivariable Cox regression treating the ALPS index as a continuous variable after adjustment for age, sex, education, and APOE ε4 carrier status are shown in the lower left. The table under the curve illustrates number at risk (%) at 2‐year intervals, to facilitate interpretation of the curves. AD, Alzheimer's disease; ALPS, analysis along the perivascular space; APOE, apolipoprotein E; CN, cognitively normal; CI, confidence interval; MCI, mild cognitive impairment; HR, hazard ratio; UKB, UK Biobank.