TABLE 2.
Linear regression models examining the cross‐sectional associations of fractal regulation with neuropathologies.
| Neuropathology | α 1 | α 2 | ||
|---|---|---|---|---|
| Estimate (95% CI) | p value | Estimate (95% CI) | p value | |
| Amyloid β | −0.008 (−0.106, 0.090) | 0.871 | 0.047 (−0.052, 0.146) | 0.349 |
| PHFtau tangles | 0.003 (−0.108, 0.115) | 0.953 | −0.063 (−0.176, 0.049) | 0.270 |
| Odds ratio (95% CI) | p value | Odds ratio (95% CI) | p value | |
|---|---|---|---|---|
| Lewy body disease | 0.790 (0.627, 0.996) | 0.047 | 0.996 (0.780, 1.270) | 0.972 |
| LATE‐NC | 0.994 (0.831, 1.188) | 0.945 | 0.992 (0.829, 1.187) | 0.929 |
| Hippocampal sclerosis | 0.804 (0.600, 1.078) | 0.144 | 0.980 (0.730, 1.318) | 0.896 |
| Gross chronic infarcts | 0.773 (0.648, 0.923) | 0.005 | 0.893 (0.748, 1.066) | 0.210 |
| Chronic microinfarcts | 0.813 (0.678, 0.974) | 0.025 | 1.021 (0.851, 1.224) | 0.822 |
| Atherosclerosis | 0.862 (0.710, 1.047) | 0.134 | 0.989 (0.811, 1.206) | 0.916 |
| Arteriolosclerosis | 0.795 (0.658, 0.960) | 0.017 | 1.028 (0.852, 1.241) | 0.769 |
| Cerebral amyloid angiopathy | 1.111 (0.927, 1.331) | 0.255 | 1.043 (0.871, 1.250) | 0.643 |
| Sensitivity analysis | Estimate (95% CI) | p value | Estimate (95% CI) | p value |
|---|---|---|---|---|
| Amyloid β | −0.090 (−0.217, 0.037) | 0.164 | 0.002 (−0.124, 0.127) | 0.978 |
| PHFtau tangles | −0.072 (−0.192, 0.047) | 0.233 | −0.118 (−0.235, −0.001) | 0.049 |
| Odds ratio (95% CI) | p value | Odds ratio (95% CI) | p value | |
|---|---|---|---|---|
| Lewy body disease | 0.694 (0.504, 0.955) | 0.025 | 0.975 (0.700, 1.359) | 0.881 |
| LATE‐NC | 1.076 (0.854, 1.355) | 0.533 | 0.995 (0.796, 1.244) | 0.965 |
| Hippocampal sclerosis | 1.109 (0.721, 1.705) | 0.637 | 0.850 (0.562, 1.286) | 0.439 |
| Gross chronic infarcts | 0.774 (0.618, 0.970) | 0.026 | 0.910 (0.732, 1.131) | 0.392 |
| Chronic microinfarcts | 0.743 (0.587, 0.941) | 0.014 | 1.007 (0.803, 1.262) | 0.954 |
| Atherosclerosis | 0.833 (0.654, 1.062) | 0.140 | 1.014 (0.797, 1.289) | 0.909 |
| Arteriolosclerosis | 0.802 (0.632, 1.017) | 0.069 | 1.064 (0.847, 1.338) | 0.592 |
| Cerebral amyloid angiopathy | 1.056 (0.836, 1.335) | 0.646 | 1.105 (0.880, 1.389) | 0.390 |
Note: Models were adjusted for age at death, sex, and education. Results represent changes in the level (for continuous outcomes) or the odds (for dichotomized outcomes) for each 1 standard deviation increase in α 1 or α 2. Sensitivity analysis was performed in participants with the time interval between last actigraphy and death of ≤2 years. Detailed results are summarized in Tables S1 and S2. LATE‐NC, limbic‐predominant age‐related TDP‐43 encephalopathy neuropathological change; PHF, paired helical filament.