Table 2. ROS-responsive materials for drug release and delivery.
DOX, doxorubicin; PEG, polyethylene glycol; PPS, propylene sulfide; DMA, N,N-dimethylacrylamide; PTX, paclitaxel; PBE, phenyl boronic ester; TPGS, d-α-tocopheryl polyethylene glycol succinate; PS, phenyl sulfide; AA, aminoacrylate.
| Mechanism for drug release | ROS-responsive linkers | Nanoplatforms for drug delivery | Applications | References |
|---|---|---|---|---|
| Carrier disassembly triggered by ROS-induced material solubility change | Thioether | DOX-loaded polymeric micelle | NCI-H460 tumor model | (161) |
| Sulfide | PEG-bl-PPS block copolymer filomicelles | Atherosclerotic mice; human plasmacytoid dendritic cells (pDCs) | (118, 120, 162) | |
| PEG-bl-PPS polymeric bicontinuous nanospheres | RAW 264.7 cells MCF7 breast cancer cells | (137) | ||
| poly(PS74-b-DMA310) micelles | RAW 264.7 cells | (163) | ||
| DOX-loaded phenyl sulfide–containing mesoporous silicon | MCF-7 breast cancer cells | (164) | ||
| Monoselenide | Monoselenide-containing amphiphilic hyperbranched copolymer micelle | HeLa cells | (165) | |
| Ferrolene | PTX-loaded ferrocene-containing amphiphilic block copolymers | A549 lung cancer cells | (166) | |
| Phenyl boronic acid | DNA-loaded charge-reversal lipidic polyplex | A549 lung tumor model | (167) | |
| Phenyl boronic ester | PBE-containing siRNA-loaded polymeric nanomedicine | U87MG glioma model | (168) | |
| Carrier degradation caused by ROS-responsive linker cleavage | Thioester | PTX-loaded TPGS-poly(β-thioester) nanoparticles | SCC-7 tumor model | (169) |
| Diselenide | DOX-loaded diselenide-crosslinked micelles | PC3 tumor model | (107) | |
| Tellurium | Cisplatin and indocyanine green–loaded tellurium-containing polymer | MDA-MB-231 tumor model | (170) | |
| Oxalate ester | Palmitoyl ascorbate hybrid micelles | 4T1 tumor model | (171) | |
| Oligoproline | PEGylated oligoproline-containing polymeric nanocarriers | Vascular smooth muscle cells (VSMCs) | (172) | |
| Aminoacrylate | AA-containing PS- oligoethylenimine (OEI)–conjugated polymer | HeLa cells | (173) | |
| ROS-responsive carrier-drug linker cleavage | Thioketal | Thioketal-linked polyphosphoester-DOX conjugate | MDA-MB-231 tumor model | (174) |