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. 2023 Dec 6;229(5):1266–1276. doi: 10.1093/infdis/jiad558

Figure 2.

Figure 2.

Blood and CSF biomarker signatures associated with SSRIs and SNRIs use. Green boxes highlight favorable mechanisms that are associated with the increased or decreased levels of the respective biomarkers and the respective effects. The orange boxes summarize the associations between SSRI and SNRI use and biomarkers, for which the interpretation of the consequences of the observed association is uncertain (being either positive or negative). Abbreviations: 8-oxo-dG, 8-oxo-2′-deoxyguanosine; BBB; blood-brain barrier; CCL2, chemokine C-C motif ligand 2; CNS, central nervous system; CSF, cerebrospinal fluid; LPS, lipopolysaccharide; MM, monocytes/macrophages; sCD14, soluble cluster of differentiation 14; sCD40L, soluble ligand of cluster of differentiation 40; SNRIs, serotonin and norepinephrine reuptake inhibitors; SSRIs, selective serotonin reuptake inhibitors; sTNFR2, soluble tumor necrosis factor receptor type 2.