Figure 3.

Whole-blood gene transcript level changes in patients with methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infection (BSI) relative to methicillin-resistant S. aureus (MRSA) BSI. A, Volcano plot showing gene transcript level differences in patients with MSSA versus MRSA BSI. Genes that had log₂-transformed fold change (log₂FC) >1 or less than −1 and had a false discovery rate (FDR) <0.10 are shown in red; genes meeting only the log₂FC or FDR criteria are shown in green or blue, respectively; and genes meeting neither criterion (NS) are shown in gray. Circled in red is a group of genes that particularly differed between the 2 groups and are further described in B. B, Log₂-transformed fold changes (log₂FC). C, g:Profiler biological processes analysis of gene transcript level differences in patients with MSSA versus MRSA BSI. For each pathway, the number of genes associated with the pathway (count) and the P value associated with the pathway are shown. Abbreviations: ATP, adenosine triphosphate; DFFA, DNA fragmentation factor-α; NADH, nicotinamide adenine dinucleotide, reduced; rRNA, ribosomal RNA.