Figure 4.

Identification of bacteria-specific host transcriptional signatures. Within each circle is the number of genes with transcript levels that differ in each comparison (eg, patients with gram-negative [GN] vs methicillin-susceptible Staphylococcus aureus [MSSA] bloodstream infection [BSI]). Gene transcript levels shared between 2 different comparisons are determined to be part of bacteria-specific response. For example, if a gene is up-regulated in patients with methicillin-resistant S. aureus (MRSA) BSI relative to both MSSA BSI and GN BSI, then the gene is defined as part of the MRSA-specific host signature. See Supplementary Table 4 for specific identities of the MRSA-specific host signature genes.