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. Author manuscript; available in PMC: 2024 May 15.
Published in final edited form as: Nat Aging. 2023 Jul 27;3(8):948–964. doi: 10.1038/s43587-023-00451-9

Extended Data Fig. 4. Mean methylation in array and RRBS methylation profiles.

Extended Data Fig. 4.

a, Mean liver methylation assayed by the Mammalian Methylation Array (HorvathMammalMethylChip40), both based on all sites in the array (left) and only sites in CpG islands (right). n = 5 samples per group. b, Mean global methylation (top), promoter methylation (middle), and gene body methylation (bottom) of liver (left) and blood (right) RRBS samples. Mean methylation was assayed across 1,014,243 CpGs (top), 11,842 promoters (middle), and 13,811 gene bodies (bottom). n = 4–7 samples per group. Two-tailed Welch’s t-test were used for statistical analysis. Schematic tissues in each panel indicate the source of the sample.