Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Main signalling pathway mechanisms of SASP in lymphoma cellular resistance. The loss of p53 and expression of NF-κB exacerbate the paracrine activity of SASP, which promotes cytokine secretion, as well as signal transduction pathways, including mTOR/NOTCH/ERK/JAK-STAT, mediate the stem-like proliferation of lymphoma senescent cells. All of these facilitate the drug resistant characteristics of lymphoma cells. SASP, senescent-associated secretory phenotype.
