Figure 1.

Overview of the molecular mechanisms of ferroptosis. The figure was drawn using Figdraw (www.figdraw.com). ALOX, arachidonate lipoxygenase; BH4, tetrahydrobiopterin; CoQ₁₀, coenzyme Q10; CoQ₁₀H₂, ubiquinol; DHODH, dihydroorotate dehydrogenase; FSP1, ferroptosis suppressor protein 1; GCH1, GTP cyclic hydrolase 1; GPX4, glutathione peroxidase 4; GSH, glutathione; GSSG, glutathione disulfide; I3P, indole-3-pyruvate; IL4i1, IL-4-induced-1; MDR1, multidrug resistance 1; PL, phospholipid; POR, cytochrome P450 oxidoreductase; PUFA, polyunsaturated fatty acid; ROS, reactive oxygen species; SLC7A11, solute carrier family 7 member 11; TFRC, transferrin receptor.