Figure 3.

Core molecular mechanisms of necroptosis. The figure was drawn using Figdraw (www.figdraw.com). cIAP1/2, cellular inhibitor of apoptosis protein 1/2; CYLD, cylindromatosis; DAMP, damage-associated molecular pattern; FADD, Fas-associated death domain; LUBAC, linear ubiquitin chain assembly complex; MLKL, mixed lineage kinase domain-like pseudokinase; P, phosphate group; RIPK, receptor-interacting protein kinase; TNFR, tumor necrosis factor receptor; TRADD, TNFR1-associated death domain protein; TRAF2, TNF receptor-associated factor 2.