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OS (A) of all patients with Sig3-positive tumors who initiated protocol therapy and (B) after excluding patients who crossed over to gemcitabine/berzosertib and (C) of all patients with Sig3-negative tumors who initiated protocol therapy and (D) after excluding patients who crossed over to gemcitabine/berzosertib. HR, hazard ratio; OS, overall survival; Sig3, signature 3.
