TABLE A1.
Biomarker Designations and Crossover
| Biomarker Characteristic | Gemcitabine Alone (n = 36), No. (%) | Did Not Cross Over, No. (%) | Crossed Over, No. (%) | P |
|---|---|---|---|---|
| RS biomarker | ||||
| RS-low | 17 (47) | 9 (53) | 8 (47) | |
| RS-high | 13 (36) | 9 (69) | 4 (31) | |
| Unknown | 6 (17) | |||
| Mutational signature 3 | ||||
| Negative | 18 (50) | 11 (61) | 7 (39) | |
| Positive | 12 (33) | 7 (58) | 5 (42) | |
| Unknown | 6 (17) | |||
| ATM expression by IHC | ||||
| Negative/low | 11 (31) | 6 (55) | 5 (45) | |
| Positive | 20 (56) | 11 (55) | 9 (45) | |
| Unknown | 5 (14) |
Abbreviations: IHC, immunohistochemistry; RS, replication stress.