Table 24.

Recommended Monitoring for Patients Taking Oral Amiodarone

Adverse Effect	Baseline Testing	Initial Follow-Up Testing	Additional Follow-Up Testing
Hypo- or hyperthyroidism	TSH (T4 and T3 if TSH abnormal)	3–6 mo	Every 6 mo
Hepatotoxicity	AST, ALT	3–6 mo	Every 6 mo
QT interval prolongation	ECG	Annually	–
Interstitial lung disease	Chest x-ray: Recommended CT chest: Not recommended	Chest x-ray: Unexplained cough or dyspnea or other signs/symptoms suspicious for interstitial lung disease	CT chest: As indicated to follow-up ongoing symptoms or chest x-ray findings
Corneal microdeposits (epithelial keratopathy)	Not recommended	Development of visual abnormalities, which may indicate optic neuropathy	–
Dermatologic (blue-gray skin discoloration), photosensitivity	Not recommended	Physical examination annually	Development of skin discoloration, severe sunburn
Neurological	Not recommended	Physical examination annually	Development of peripheral neuropathy or other neurological abnormalities

ALT indicates alanine transaminase; AST, aspartate transaminase; CT, computed tomography; ECG, electrocardiogram; TSH, thyroid-stimulating hormone; and TdP torsades de pointes.