TABLE A5.
Treatment Intensity and Compliance of Pemetrexed Plus Carboplatin or Cisplatin Arm
| Category | Induction Phase | |||||
|---|---|---|---|---|---|---|
| No. | Mean | SD | Median | Min | Max | |
| Pemetrexed | ||||||
| No. of cycles | 74 | 3.80 | 0.76 | 4.00 | 2.00 | 6.00 |
| Relative dose intensity, % | 74 | 97.28 | 8.15 | 99.62 | 52.55 | 108.89 |
| Dose reduction | 3 | |||||
| Temporally interruption | 0 | |||||
| Cisplatin | ||||||
| No. of cycles | 8 | 3.50 | 0.76 | 4.00 | 2.00 | 4.00 |
| Relative dose intensity, % | 8 | 79.43 | 22.43 | 83.68 | 40.99 | 101.35 |
| Dose reduction | 2 | |||||
| Temporally interruption | 1 | |||||
| Carboplatin | ||||||
| No. of cycles | 66 | 3.80 | 0.77 | 4.00 | 2.00 | 6.00 |
| Actual dose intensity, mg/week | 66 | 190.60 | 48.83 | 187.57 | 94.04 | 296.67 |
| Dose reduction | 13 | |||||
| Temporally interruption | 0 | |||||
| Maintenance Phase | ||||||
| Category | No. | Mean | SD | Median | Min | Max |
| Pemetrexed | ||||||
| No. of cycles | 58 | 12.91 | 8.49 | 10.00 | 5.00 | 43.00 |
| Relative dose intensity, % | 58 | 96.17 | 10.00 | 99.06 | 56.68 | 121.73 |
| Dose reduction | 5 | |||||
| Temporally interruption | 0 | |||||
NOTE. Two patients received six cycles of induction pemetrexed/carboplatin.
Abbreviation: SD, standard deviation.