TABLE 2.
Adjusted Logistic Regression for pCR (n = 31,138)
| Variable | pCR v RD (pCR Rate = 8,993/31,138, 28.9%) | ||
|---|---|---|---|
| OR (95% CI) | P | Overall P | |
| Race/ethnicity | <.001 | ||
| NHW | Ref | ||
| Hispanic | 1.19 (1.08 to 1.31) | .001 | |
| NHA | 0.92 (0.8 to 1.06) | .25 | |
| NHB | 0.89 (0.83 to 0.95) | .001 | |
| Other | 0.98 (0.76 to 1.25) | .86 | |
| Age, years | <.001 | ||
| ≥50 | Ref | ||
| <50 | 1.27 (1.2 to 1.34) | <.001 | |
| Charlson/Deyo comorbidity score | .001 | ||
| 0 | Ref | ||
| 1 | 0.89 (0.81 to 0.96) | .005 | |
| ≥2 | 0.8 (0.68 to 0.95) | .009 | |
| Facility type | <.001 | ||
| Academic/research | Ref | ||
| Integrated network | 0.95 (0.88 to 1.01) | .11 | |
| Comprehensive community | 0.86 (0.81 to 0.91) | <.001 | |
| Community | 0.77 (0.68 to 0.87) | <.001 | |
| Facility location | .003 | ||
| South | Ref | ||
| Midwest | 1.03 (0.96 to 1.1) | .43 | |
| Northeast | 0.89 (0.82 to 0.96) | .002 | |
| West | 1 (0.93 to 1.09) | .90 | |
| Insurance type | <.001 | ||
| Private | Ref | ||
| Government | 0.79 (0.75 to 0.84) | <.001 | |
| None | 0.83 (0.72 to 0.96) | .01 | |
| Clinical T-stage | <.001 | ||
| T1 | Ref | ||
| T0/IS | 0.81 (0.38 to 1.73) | .59 | |
| T2 | 1.02 (0.96 to 1.09) | .56 | |
| T3 | 0.73 (0.66 to 0.8) | <.001 | |
| T4 | 0.58 (0.51 to 0.66) | <.001 | |
| Clinical N-stage | <.001 | ||
| N0 | Ref | ||
| N1 | 0.9 (0.86 to 0.96) | <.001 | |
| N2 | 0.72 (0.64 to 0.81) | <.001 | |
| N3 | 0.85 (0.75 to 0.96) | .008 | |
| Grade | <.001 | ||
| 1 | Ref | ||
| 2 | 1.48 (1.02 to 2.14) | .04 | |
| 3 | 2.7 (1.88 to 3.87) | <.001 | |
| Longer interval from diagnosis to chemotherapy | 0.95 (0.94 to 0.96) | <.001 | <.001 |
| Longer interval from chemotherapy to surgery | 1.02 (1.02 to 1.03) | <.001 | <.001 |
NOTE. Model also adjusted for tumor size, surgery type, education level, income level, and community type. Estimates for intervals from diagnosis to chemotherapy and chemotherapy to surgery are for the 1-week increase.
Abbreviations: IS, in situ; N, node; NHA, Non-Hispanic Asian; NHB, Non-Hispanic Black; NHW, Non-Hispanic White; OR, odds ratio; pCR, pathologic complete response; RD, residual disease; Ref, reference; T, tumor.