TABLE A1.

Modified Common Terminology Criteria for Adverse Events v4.03 Grades of Cardiomyopathy

Grade	Definition
Grade 1	Not applicable
Grade 2	Resting EF <50%-40%; 10%-19% absolute drop from baseline
Grade 3	Resting EF 39%-20%; >20% absolute drop from baseline; medication indicated or initiated
Grade 4	Resting EF <20%; refractory or poorly controlled heart failure due to drop in ejection fraction; on medical management; intervention such as ventricular assist device, intravenous vasopressor support, or heart transplant indicated
Grade 5	Death

Abbreviation: EF, ejection fraction.