TABLE A2.
Genetic Variants Associated With Anthracycline-Associated Cardiomyopathy (replicated one or more times in an independent sample)
| Single-Nucleotide Polymorphism | Risk Allele/Genotype | Other Allele/Genotype |
|---|---|---|
| rs17863783 (UGT1A6)49 | T | G |
| rs1786814 (CELF4)50,a | GA/AA | GG |
| rs2229774 (RARG)51 | A | G |
| rs2232228 (HAS3)52,b | AA | GG |
| rs4149178 (SLC22A7)53 | G | A |
| rs4982753 (SLC22A17)53 | T | C |
| rs7627754 (ABCC5)54 | TT | AT/AA |
| rs7853758 (SLC28A3)49 | A | G |
| rs2815063 (Intergenic)55 | A | C |
| rs6689879 (MAGI3/PHTF1)56,c | C | T |
a
rs1786814 (CELF4) assessed as SNP x anthracycline (>300 mg/m2).
b
rs2232228 (HAS3) assessed as SNP x anthracycline (>250 mg/m2).
c
Identified in African American survivors of childhood cancer.