TABLE A6.
Multivariable Associations Comparing Individuals Within IGHG-Defined Risk Groups Based Upon Cumulative Doses of Anthracyclines and Chest Radiation Adjusting for rs2229774
| Variable | HR (95% CI) | P |
|---|---|---|
| Race | ||
| White | Ref | |
| Non-White | 1.44 (0.93 to 2.24) | .11 |
| Sex | ||
| Male | Ref | |
| Female | 0.81 (0.57 to 1.14) | .23 |
| Age at diagnosis, years | ||
| 0-4 | Ref | |
| 5-9 | 1.37 (0.85 to 2.21) | .20 |
| 10-14 | 1.08 (0.66 to 1.76) | .77 |
| 15-19 | 1.07 (0.61 to 1.87) | .81 |
| No. of cardiovascular risk factors | ||
| None | Ref | |
| 1 | 0.98 (0.64 to 1.49) | .92 |
| ≥2 | 1.30 (0.82 to 2.04) | .27 |
| IGHG risk group | ||
| Low | Ref | |
| Moderate, without anthracycline | 0.71 (0.08 to 6.41) | .76 |
| Moderate, with anthracycline | 1.70 (0.69 to 4.19) | .25 |
| High, without anthracycline | 6.71 (2.35 to 19.16) | <.001 |
| High, with anthracycline | 3.95 (1.67 to 9.34) | .002 |
| IGHG low-risk group | ||
| GLS normal/NT-proBNP normal | Ref | |
| GLS abnormal/NT-proBNP normal | 1.15 (0.29 to 4.48) | .84 |
| GLS normal/NT-proBNP abnormal | 0.00 (0.00 to 3.34) | .27 |
| GLS abnormal/NT-proBNP abnormal | 0.00 (0.00 to 18.6) | .62 |
| GLS normal/NT-proBNP unavailable | 2.07 (0.68 to 6.27) | .20 |
| GLS abnormal/NT-proBNP unavailable | 1.78 (0.36 to 8.77) | .48 |
| IGHG moderate-/high-risk group, without anthracycline | ||
| GLS normal/NT-proBNP normal | Ref | |
| GLS abnormal/NT-proBNP normal | 0.72 (0.21 to 2.45) | .60 |
| GLS normal/NT-proBNP abnormal | 0.40 (0.08 to 1.91) | .25 |
| GLS abnormal/NT-proBNP abnormal | 0.88 (0.30 to 2.58) | .82 |
| GLS normal/NT-proBNP unavailable | 1.83 (0.22 to 15.14) | .57 |
| GLS abnormal/NT-proBNP unavailable | 0.00 (0.00 to 1.79) | .99 |
| IGHG moderate-/high-risk group, with anthracycline | ||
| GLS normal/NT-proBNP normal | Ref | |
| GLS abnormal/NT-proBNP normal | 0.98 (0.50 to 1.92) | .96 |
| GLS normal/NT-proBNP abnormal | 2.15 (1.15 to 4.01) | .016 |
| GLS abnormal/NT-proBNP abnormal | 4.29 (2.33 to 7.89) | <.001 |
| GLS normal/NT-proBNP unavailable | 2.66 (1.34 to 5.29) | .005 |
| GLS abnormal/NT-proBNP unavailable | 4.24 (2.09 to 8.60) | <.001 |
NOTE. Adjusted for age at baseline and rs2229774.
Abbreviations: GLS, global longitudinal strain; HR, hazard ratio; IGHG, International Guideline Harmonization Group; NT-proBNP, N-terminal-pro-B-type natriuretic peptide; Ref, reference.