FIG 1.

Genomic driver landscape in newly diagnosed multiple myeloma. (A) Driver genes significantly involved by single-nucleotide variants and indels using four different driver discovery tools (Fishhook, Oncodriver, MutSigCV, and dNdScv). X-axis label colors represent the COSMIC census annotation for each driver gene: red = oncogenes; blue = TSG; black = unknown. (B) Significant broad and focal copy-number changes detected by GISTIC: red = gain, blue = loss. (C-E) Kaplan-Meier curves for OS according to (C) RB1 allelic status, (D) presence of chromothripsis-CNV.Sig, and (E) APOBEC activity. CNV.Sig, CNV signature; GISTIC, Genomic Identification of Significant Targets in Cancer; OS, overall survival; TSG, tumor-suppressor genes; WT, wild type.